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Outcomes: clinically relevant variables including absolute and percentage change in body weight, HbA1c reduction, cardiometabolic outcomes (e.g., major adverse cardiovascular events [MACE], hospitalizations), and adverse event incidence (e.g., gastrointestinal symptoms, hypoglycemia)

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BioRad, Hercules, CA, USA) and real-time quantitative PCR (qPCR) was performed using a TaqMan 7900 Sequence Detection System with TaqMan Universal PCR Master Mix and TaqMan Gene Expression Assays (Applied Biosystems, Foster City, CA, USA)

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On arrival: Store vials in a cool, dry place away from heat and direct sunlight